A Smad transcriptional corepressor
Article Abstract:
A study was conducted to show that Smad2 associates with the ubiquitously expressed homeodomain protein, TGIF. The formation of mutually exclusive complexes were determined by the relative levels of Smad corepressors and coactivators within the cell. A two-hybrid library with a LexA fusion was utilized to determine the proteins that participate in transforming growth factor-beta signaling.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
The polycomb protein Pc2 is a SUMO E3
Article Abstract:
Research shows that the transcriptional corepressor carboxy-terminus binding protein, CtBP, undergoes modification on a single lysine residue mediated by SUMO-1 or SUMO-3. Furthermore, the polycomb group protein Pc2 is a SUMO E3 and recruits both CtBP and Ubc9 to polycomb group bodies, which may influence transcription by mediating sumoylation of specific target proteins.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria
Article Abstract:
The metabolite binding domains or riboswitches control operons and exhibit high affinity and high selectivity for guanine. Results show that in Bacillus subtilis seven distinct target molecules in conjunction with known classes of riboswitches control 68 genes involved in metabolic pathways.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Transcriptional repressor CopR: dissection of stabilizing motifs within the C terminus. Expression and purification of four different rhizobial acyl carrier proteins
- Abstracts: Distribution and diversity of natural product genes in marine and freshwater cyanobacterial cultures and genomes
- Abstracts: Transfer of transposon Tn916 from Bacillus subtilis into a natural soil population. Temperature-dependent induction of an acid-inducible stimulon of Escherichia coli in broth
- Abstracts: Purification and characterization of a keratinase from a feather-degrading Bacillus licheniformis strain. An altered Pseudomonas diversity is recovered from soil by using nutrient-poor Pseudomonas-selective soil extract media
- Abstracts: New thermosensitive delivery vector and its use to enable nisin-controlled gene expression in Lactobacillus gasseri