A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q
Article Abstract:
The spleen and C3 provides resistance against blood-borne S. pneumoniae infection, to understand the mechanisms involved SIGN-RI is studied, a lectin that captures microbial polysaccharides in spleen. It is found that SIGN-R1 directly bound the complement C1 subcomponent, C1q, and assembled a C3 convertase, but without the traditional requirement for either antibody or factor B.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling
Article Abstract:
An approach is described to pharmacologically interrogate the PI3-K family. It is found that p110alpha is the primary insulin-responsive PI3-K in cultured cells, whereas p110beta is dispensable but sets a phenotypic threshold for p110alpha activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Induction of ploidy level increments in an asporogenous industrial strain ofthe yeast Saccharomyces cerevisiae by UV irradiation
- Abstracts: Increased inactivation of Saccharomyces cerevisiae by protraction of UV irradiation. Induction of heat, freezing and salt tolerance by heat and salt shock in Saccharomyces cerevisiae
- Abstracts: Cse4p is a component of the core centromere of Saccharomyces cerevisiae. The ways of PARP
- Abstracts: Bacterial outer membrane vesicles and the host-pathogen interaction. Exonic splicing enhances in fission yeast: Functional conservation demonstrates an early evolutionary origin
- Abstracts: Hox and wings. The choroid plexus in the rise, fall and repair of the brain