A functional genomic strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock
Article Abstract:
The identification of a novel clock gene clockwork orange (cwo), a transcriptional repressor in Drosophila is described. It is proposed that the competition between cyclic CLK-CYC activity and the adjustable threshold imposed by cwo keeps E-box mediated transcription within the controllable range of its activity which renders a Drosophila circadian clock capable of generating high-amplitude oscillation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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Drosophila lacking microRNA miR-278 are defective in energy homeostasis
Article Abstract:
Evidence to show that the microRNA miR-278 plays a role in the control of energy homeostasis in Drosophila is presented. miR-278 acts by a different mechanism, at least partly through regulation of expanded transcript to control insulin sensitivity in adipose and peripheral tissues.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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