Molecular characterization of Clostridium perfringens isolates from humans with sporadic diarrhea: Evidence for transcriptional regulation of the beta2-toxin-encoding gene
Article Abstract:
The 14 cpe(super +) Clostridium perfringens fecal isolates associated with human sporadic diarrhea (SD) in England is characterized to test the association of beta2 toxin (CPB2) with human gastrointestinal GI diseases. The results have shown that all C. perfringens plasmid cpe isolates carry cpb2 and that there is a positive correlation between cpb2 transcription levels and the amount of CPB2 produced by cpe(super +)/cpb2(super +) C. perfringens human SD isolates.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2005
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Comparison of the levels of heat resistance of wild-type cpe knockout, and cpe plasmid-cured Clostridium perfringens type A strains
Article Abstract:
An enterotoxin (cpe) plasmid is cured from a Clostridium perfringens non-food-borne gastrointestinal disease (NFBGID) isolate, and the heat resistance levels of wild-type, cpe knockout, and cpe plasmid-cured strains are compared. Results demonstrate that wild-type cpe has no influence in mediating high-level heat resistance in C. perfringens and the cpe plasmid does not confer heat sensitivity on NFBGID isolates.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2005
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Antisense-RNA-mediated decreased synthesis of small, acid-soluble spore proteins leads to decreased resistance of Clostridium perfringens spores to moist heat and UV radiation
Article Abstract:
Antisense RNA is used to decrease the levels of [alpha]/[beta]-type small, acid-soluble spore proteins (SASP) in Clostridium perfringens spores, which in turn have reduced the resistance to both moist heat and ultraviolet (UV) radiation but not to dry heat. The results have highlighted the [alpha]/[beta]-type SASP's role in the resistance of Clostridium perfringens spores.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2007
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