A genomewide single-nucleotide-polymorphism panel for Mexican American admixture mapping
Article Abstract:
An admixture study in Mexican Americans (MAM) was conducted by defining genomewide single-nucleotide-polymorphism (SNP) panel that can distinguish between chromosomal segments of Amerindian (AMI) or European (EUR) ancestry. It is shown that using realistic simulation parameters this panel of SNP ancestry-informative markers provides good power for detecting disease-associated chromosomal segments for genes with modest ethnicity risk ratios.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping
Article Abstract:
The ability of selected single-nucleotide polymorphisms (SNPs) to extract continental ancestry information in African American (AFA) subjects is investigated and parameters for admixture mapping, which requires a genomewide panel of relatively evenly spaced ancestry-informative markers (AIM) is explored. A set of AFA SNP AIMs is derived which improves power for admixture mapping in African Americans when ethnicity risk ratios are modest.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels
Article Abstract:
An estimated 1,343 single-nucleotide polymorphisms (SNPs) are genotyped in 1,184 African Americans from the Health, Aging and Body Composition (Health ABC) Study to identify genes influencing the levels of the inflammatory markers. Results reveal a significant association of interleukin 6 soluble receptor (IL-6SR) with European ancestry on chromosome 1 in a region that includes the gene for this receptor (IL-6R).
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Genetic interactions between Drosophila melanogaster menin and Jun/Fos. Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains
- Abstracts: A genome-wide survey of the evolutionarily conserved Wnt pathways in the sea urchin Strongylocentrotus purpuratus
- Abstracts: Application of the [3.super.H]Leucine incorporation technique for quantification of bacterial secondary production associated with decaying wetland plant litter
- Abstracts: A requirement for NF-protocadherin and TAF1/Set in cell adhesion and neural tube formation. The mouse Ovol2 gene is required for cranial neural tube development
- Abstracts: Reduction of sample heterogeneity through use of population substructure: An example from a population of African American families with sarcoidosis