Reduction of sample heterogeneity through use of population substructure: An example from a population of African American families with sarcoidosis
Article Abstract:
A population of African American (AA) families with sarcoidosis is clustered into subsets in order to examine linkage analysis stratified by ancestry similarity estimated from highly polymorphic genetic markers, instead of race, as a means of reducing sample heterogeneity. Strong evidence for previously unidentified population-specific effects is provided for the presence of sarcoidosis-susceptibility genes in the AA sample.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
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A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans
Article Abstract:
A genomewide scan of individuals of African American (AA) origin was conducted to identify susceptibility loci for nicotine dependence (ND) in an African American sample. Results revealed significant linkage on chromosome 10q22 and suggestive linkage on chromosomes 9, 11 and 13 for major genetic determinants of ND in the AA sample, and three regions on chromosomes 15, 17 and 18 that showed potential linkage to ND.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
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Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study
Article Abstract:
The colon neoplasia sibling study is employed to conduct a comprehensive genome-wide scan for the identification of susceptibility genes for cancer. The analysis of the detailed clinical information, unaffected siblings and family history was found to be extremely beneficial for the linkage study.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2008
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