A protein phosphatase functions to recycle RNA polymerase II
Article Abstract:
A protein phosphatase recycles RNA polymerase II, based on work in which a cDNA clone that encodes a 15-kD polypeptide, which reconstitutes a very specific carboxy-terminal domain (CTD) phosphatase activity, was isolated. The reconstitution takes place with the polypeptide working with RNA polymerase II (RNAPII, the CTD phosphatase). The phosphatase stimulates elongation by RNAPII, but independent of phosphatase catalysis. The CTD phosphatase is active in ternary elongation complexes.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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SNAP(sub.c): a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain
Article Abstract:
SNAP(sub.c), that is, snRNA activating protein complex, a core promoter factor with a built-in DNA-binding damper that the Oct-1 POU domain deactivates, is discussed. The roles of SNAP(sub.c) components, of which there are five, have been determined in some processes it is known to be involved in by putting parts of it together in vitro.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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Transcription elongation factor hSPT5 stimulates mRNA capping
Article Abstract:
Stimulation of mRNA capping by transcription elongation factor hSPT5, the human homolog of yeast elongation factor SPT5, is discussed based on recent research. TFIIH-phosphorylated CRD stimulates guanylylation in an increase not additive with hSPT5, and hSPT5 did not increase activity of the guanylyltransferase fragment.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
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