PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
Article Abstract:
The role of the nuclear receptor PPARgamma in myelomonocytic cell differentiation and uptake of oxidized low-density lipoprotein (LDL) was investigated. PPARgamma protein was expressed in peripheral blood monocytes and tissue macrophages using immunofluorescence microscopy. Results show that PPARgamma is induced in monocytes after being exposed to oxidized LDL and is expressed in the foam cells of atherosclerotic lesions at high levels. These findings suggest a novel signaling pathway that regulates differentiation and lipid metabolism in monocytic cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Through thick and thin: wasting, obesity, and TNF-alpha
Article Abstract:
A review of studies of the role of tumor necrosis factor alpha (TNF-alpha) in energy metabolism is presented. TNF-alpha was initially isolated as a polypeptide with selective cytotoxic activity against tumor cells. It had been identified as the factor causing hyperlipidemia via lipoprotein lipase suppression during severe weight loss, or cachexia. It has also been associated with obesity and the disorders in glucose homeostasis accompanying it. The ability of TNF-alpha to mediate the most extreme states of catabolism and anabolism was thus explored.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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PPARgamma in monocytes: less pain, any gain?
Article Abstract:
The nuclear receptor PPARgamma demonstrates a biological function in leukemic cells of the myeloid lineage. Studies show that ligand activation of PPARgamma regulates monocyte biology in several ways that offer potential therapeutic options for obesity. PPARgamma mRNA is expressed at higher levels in peritoneal macrophages produced with thioglycollate than in monocytes elicited from the bone marrow.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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