Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes

Article Abstract:

A study of the effect of p53, a tumor suppressor gene on transformation of hematopoietic cells shows that loss of p53 results in immortalization and tumorigenesis. Infection of fetal liver cells from wild-type and p53-/- mice with oncogenic retroviruses resulted in transformed colonies with myc-raf and raf virus. However, only the transformed cells from p53-/- mice proliferated in liquid culture. The p53 protein is probably involved in cell senescence.

Tumor suppressor genes, Carcinogenesis, Cell transformation

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Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death

Article Abstract:

Transgenic mice expressing autoantibodies for engineered membrane-bound antigens were studied to elucidate the events leading to B cell elimination. The results showed that the elimination of self-reactive B cells proceeds first through developmental arrest followed by cell death. These were observed as distinct steps in the elimination process. Based on these findings, a pathway for the elimination of self-reactive B cells is proposed.

Autoantibodies, Cell death, Autoimmunity, B cells

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Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor

Article Abstract:

T cell signaling was analyzed to determine the regulatory roles of cell-derived40 ligand (CD40L)/CD40, FasL/Fas, and B cell antigen receptors. The CD4+ T cells express the CD40L and FasL genes when reacting with B cells during the elimination of self-antigen presenting B cells. The CD40L and Fas genes also interact to modulate the fate of the B cells such as cell proliferation and elimination of tolerant B cells.

Genetic aspects, Cell adhesion molecules, Gene expression, Immune system, Lymphocytes

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