Physical interaction of the retinoblastoma protein with human D cyclin
Article Abstract:
The complexes formed by cyclins D1 and D3 with the retinoblastoma protein (pRb) are similar to that formed by several oncoproteins. These complexes are also disrupted by the adenovirus E1A oncoprotein and derived peptides. Moreover, it was found that these interactions are distinct from that of cyclins A and E with pRb, which can induce pRb hyperphosphorylation. Cyclin D1 activity may also be regulated by its association with pRb.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
Article Abstract:
The role of the tumor suppressor retinoblastoma protein (pRB) in muscle cell differentiation and development was investigated. The results showed that pRB interacts with MyoD to induce cell cycle arrest and in the production and maintenance of the terminally differentiated phenotype of muscle cells. The interaction between MyoD and pRB involves a portion of the pocket and the basic helix-loop-helix domains, respectively.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Stem cell research goes underground: The RETINOBLASTOMA-RELATED gene in root development
Article Abstract:
A gene called RETINOBLASTOMA-RELATED (RBR), first discovered in mammalian systems through its involvement in oncogenesis, is important for the regulation of stem cell maintenance in plants. Data suggest that suppression of RBR function causes an increase in the number of stem cells in the root, which is likely due to prolonged maintenance of stem cell identity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Structural and functional organization of the Yersinia pestis bacteriocin pesticin gene cluster. The gene cluster directing O-antigen biosynthesis in Yersinia enterocolitica serotype O:8:identification of the genes for mannose and galactose biosynthesis and the gene for the O-antigen polymerase
- Abstracts: Categorization of notes used by female red-winged blackbirds in composite vocalizations. Sex determination of the Whooping Crane by analysis of vocalizations
- Abstracts: Deleterious mutations and the origin of the meiotic ploidy cycle. Heterozygote advantage and the evolution of a dominant diploid phase
- Abstracts: Determination of the respiration kinetics for mycelial pellets of Phanerochaete chrysosporium. Succession of bacterial communities during early plant development: Transition from seed to root and effect of compost amendment
- Abstracts: Electrophoretic mobilities of Escherichia coli O157:H7 and wild-type Escherichia coli strains. Inactivation of Escherichia coli by titanium dioxide photocatalytic oxidation