Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

Article Abstract:

Short single stranded DNA nucleotides having 16-40 nucleotides can stimulate the binding of human and murine p53 proteins to a p53 response element in supercoiled DNA but not the binding of a split p53 in which the C-terminal is missing. The p53 tumor suppressor protein which is activated when DNA is damaged, has an activation center, a DNA binding domain and an oligomerization domain. p53 activates many genes when the concentration of DNA damaging agents is high.

Analysis, DNA binding proteins

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Splicing into senescence: The curious case of p16 and p19ARF

Article Abstract:

The cyclin-dependent kinase inhibitor p16 is implicated in cell cycle regulation and cellular senescence, and its loss leads to a genetic predisposition to malagnant melanoma and pancreatic cancer. Its discovery was the result of advances in cancer genetics and cell cycle regulation, and was linked to the discovery of genomic deletions. P19ARF is a novel transcript with an identical 3' sequence to p16, but with a unique 5' end.

Aging, Observations, Cell research, Cytological research

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