Anchors away! Fos Fosters anchor-cell invasion
Article Abstract:
A simple and genetically tractable cellular assay in the worm is described for elucidating the molecular processes that underline cell invasion in vivo. Demonstrations also reveal that the transcription factor Fos is required for cell invasion and identify three of its downstream target genes, encoding a matrix metalloproteinase, hemicentin, and a fat-like protocadherin.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8
Article Abstract:
The nuclear enrichment of proteasome through the function of Cut8, a nuclear envelope protein is due to Rhp6/Ubc2/Rad6 and ligating enzymes is a nuclear envelope protein that is responsible for the enrichment of proteasome in the nucleus and the nuclear membrane. The retention of nuclear proteasome is enhanced by Rhp6 through regulating Cut8.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Forcing the third dimension
Article Abstract:
An insight into the molecular basis of tissue-specific differentiation is provided. It is shown that remodeling of the extracellular matrix by the matrix metalloproteinase MT1-MMP contributes to the three-dimensional development of white adipose tissue in mice.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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