Wnt signals from the neural tube block ectopic cardiogenesis

Article Abstract:

Research demonstrates that repression of cardiogenesis in the adjacent anterior paraxial mesendoderm by the neural tube can be overcome by the ectopic expression of Wnt antagonist, which suggests that Wnt signals from the neural tube block cardiogenesis in vertebrates.

Abnormalities, Genetic aspects, Neural tube, Neural tube defects, Cardiogenic shock

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Inhibition of Wnt activity induces heart formation from posterior mesoderm

Article Abstract:

Results demonstrate that the combined effect of the Wnt activity along the anterior-posterior axis and bone morphogenic protein signaling along the dorsal-ventral axis induce cardiogenesis. Data reveal that Wnt signal inhibition promotes heart formation in the anterior lateral mesoderm and Wnt activity in the posterior lateral mesoderm promotes blood development.

Statistical Data Included, Physiological aspects, Heart, Growth, Erythropoiesis, Bone morphogenetic proteins

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Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle

Article Abstract:

The study shows that although myogenesis in the cranial paraxial mesoderm is induced by Wnt signals from the dorsal neural tube, myogenesis in the cranial paraxial mesoderm is blocked by these same signals. The findings suggest that Wnt and BMP signals locally repress head muscle formation, induced by antagonists of these signaling pathways secreted by adjacent tissues.

Science & research, Mesoderm, Myogenesis

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