Antisense-Mediated depletion reveals essential and specific functions of MicroRNAs in Drosophila development
Article Abstract:
The injection of 2'O-methyl antisense oligoribonucleotides into early 'Drosophila' embryos that leads to specific and efficient depletion of microRNAs and permits systematic loss-of-function analysis in vivo is demonstrated. MicroRNAs act as specific and essential regulators in a wide range of developmental processes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
The developmental miRNA profiles of zebrafish as determined by small RNA cloning
Article Abstract:
The MicroRNA (miRNA) profile of the zebrafish Danio rerio resolved in a developmental and cell type-specific manner is described. A rough estimate of the breadth of gene regulation by miRNAs within one species and the extent of cross-species conversation of specific miRNA-target relationship is revealed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
A novel class of small RNAs in mouse spermatogenic cells
Article Abstract:
The identification of a novel class of small RNAs in the mouse male germline termed piwi-interacting RNAs (piRNAs) is reported. A subpopulation of piRNAs is associated with polysomes, suggesting their potential role in translational regulation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling
- Abstracts: Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesis
- Abstracts: Coordination of replication and transcription along a Drosophila chromosome. Drosophila argonaute-2 is required early in embryogenesis for the assembly of centric/centromeric heterochromatin, nuclear division, nuclear migration, and germ-cell formation