Antisense transcription controls cell fate in Saccharomyces cerevisiae
Article Abstract:
The meiotic entry in Saccharomyces cerevisiae is controlled by antisense-mediated regulation of Initiator of Meiosis 4 (IME4), a gene required for initiating meiosis. The strength of the promoter driving either sense or antisense transcription from the IME4 locus is found to be cell-type specific and IME4 sense transcription has determined a cell-type capable of meiosis, whereas IME4 antisense transcription has determined a cell-type incapable of meiosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Degradation-mediated protein quality control in the nucleus
Article Abstract:
The discovery of protein quality control degradation systems in Saccharomyces cerevisiae is reported that is defined by San1p. It is proposed that San1p-mediated degradation acts as the last line of protreolytic defense against the deleterious accumulation of aberrant proteins in the nucleus and that analogous systems exist in other eukaryotes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Mechanism of cross-species prion transmission: An infectious conformation compatible with two highly divergent yeast prion proteins
Article Abstract:
The relationship between prion strains and species barriers is explored by creating distinct synthetic prion forms of the yeast prion protein Sup35. A strain conformation of Sup35 that allows transmission from the S. cerevisiae (Sc) Sup35 to the highly divergent C. albicans (Ca) Sup35 both in vivo and in vitro is identified.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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