Assembly of an active translation initiation factor complex by a viral protein
Article Abstract:
A study is presented to establish that the herpes simplex virus-1 (HSV-1) ICP6 polypeptide associates with eIF4G, the cap-binding protein, to promote eIF4F complex assembly. The factors which are capable of interacting with eIF4G and promoting eIF4G complex assembly may play important roles in a variety of processes where translation complexes need to be remodeled or assembled on populations of newly synthesized or derepressed mRNAs.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures
Article Abstract:
The checkpoint mediator protein Claspin is indespensable for the ATR-dependent phosphorylation of Chk1 in response to stalled DNA replication forks in Xenopus egg extracts. Site-specific phosphorylation of a checkpoint mediator protein is a crucial determinant in the discrimination between various checkpoint-inducing structures.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiscent cells.
Article Abstract:
A study on contribution of translation initiation factor, eIF4E, phosphorylation in herpes simplex virus-1(HSV-1) growth is conducted. The results reveal that phosphorylation of eIF4E by mnk-1 is critical for viral protein synthesis and replication.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The cyro-EM structure of a translation initiation complex from Escherichia coli. Nascent ribosomes
- Abstracts: A first assessment of genetic variation in Welwitschia mirabilis hook. Programmed cell death and hybrid incompatibility
- Abstracts: PCR assay of the groEL gene for detection and differentiation of Bacillus cereus group cells. part 2 Combined immunomagnetic separation-molecular beacon-reverse transcription-PCR assay for detection of hepatitis A virus from environmental samples
- Abstracts: Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. A unified nomenclature system for the Drosophila odorant receptors
- Abstracts: Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis