Permutation tests for a multiple loci affecting a quantitative character
Article Abstract:
The conditional empirical threshold (CET) and the residual empirical threshold (RET) are two permutation-based methods of detecting minor quantitative trait loci (QTL). CET is a nonparametric test based on conditioning on markers linked to major QTLs but its applicability is limited to regions of the genome that are not linked to the major QTL. RET is a structural model for the effect of major QTLs and develops thresholds using the residuals for quantitative characterization.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1996
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Prediction of selection response for threshold dichotomous traits
Article Abstract:
A study was conducted to evaluate a formula for predicting selection response to a truncation generation for a dichotomous trait under polygenic additive inheritance. The formula was based on the threshold liability concept and on the normality assumption of the joint distribution. The formula also explains the response assymetry when trait prevalence and selection rate vary from 1/2 by a bivariate normal integral number.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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