Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
Article Abstract:
Aurora-A (AurA) has acted as a tumor suppressor by suppressing neuroblasts (NB) self-renewal and promoting neuronal differentiation during larval brain development in Drosophila. A novel pathway that involves AurA, atypical protein kinase C (aPKC), Numb and Notch is presented for the regulation of NB self-renewal versus neuronal differentiation during the asymmetric division of Drosophila larval NB.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development
Article Abstract:
An investigation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN 10) tumor suppressor gene functions that eluded single mutant analyses, using a Caenorhabditis elegans genome-wide screen is presented. The worm PTEN homolog daf-18 has a role in the germline or embryos, in addition to the known role in dauer and life span regulation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
OVCAI: emerging as a bona fide tumor suppressor
Article Abstract:
The embryonic lethality of Ovarian Cancer genes 1 and 2 (Ovca1 and Ovca2) is described. An attempt made to determine whether Ovca 1 acts as a tumor suppressor in vivo is examined further.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cellular signaling: pivoting around PDK-1
- Abstracts: The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis
- Abstracts: A quantitative trait locus analysis of natural genetic variation for Drosophila melanogaster oxidative stress survival
- Abstracts: Acetylation in histone H3 globular domain regulates gene expression in yeast. Discoveries of nicotinamide riboside as a nutrient and conserved Nrk genes establish a preiss-handler independent route o NAD (super +) in fungi and humans
- Abstracts: When contractile proteins go bad: The sarcomere and skeletal muscle disease