The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis
Article Abstract:
A Drosophila transmembrane called molecule kekkon 1 (kek1) was identified. It was found to function as an inhibitor of epidermal growth factor receptor (EGFR) and a negative regulator of EGFR tyrosine kinase activity. A drop in kek1 activity was observed to cause an increase in EGFR signaling. It was also noted that transmembrane molecule kek1 is created during oogenesis as a response to the Gurken/EGFR signalling pathway.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis
Article Abstract:
Research demonstrates that the timing of follicle cell differentiation in Drosophila is controlled by the Notch ligand Delta sending signals from germ cells. Data indicate that in the early oogenesis, Delta signals from the germ line to Notch and controls polar and stalk follicle cells differentiation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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