Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II

Article Abstract:

The TATA box-binding protein (TBP)-associated factors (TAFs) play an important role in regulation of transcription and selection of promotor through contacts with core promoter elements. The transcriptional control regions of protein coding genes in eukaryotes are of two types, a core promoter and an upstream or downstream regulatory element. The core promoter nucleates the binding of an initiation complex of RNA polymerase II and other accessory factors such as TFIIA, TFIIB and TFIID capable of transcription in the absence of activators. TAFs are subunits of TFIID.

Proteins, Protein synthesis

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A surface of Esherichia coli sigma super70 required for promoter function and antitermination by phage lambda Q protein

Article Abstract:

A surface of Escherichia coli sigma initiation factor sigma super 70 is necessary for antitermination and promoter activity by phage lambda Q protein. Sigma super 70 of E. coli not only functions in promoter recognition and DNA strand opening, but also in mediation of transformation of RNA polymerase (RNAP) to the form that opposes termination by the phage lambda gene Q protein. Mutations show a locus of sigma 70 that is vital to stability and formation of open promoter complex, probably as a result of mediating protein RNAP core interactions.

Genetic aspects, Observations, Escherichia coli, Promoters (Genetics)

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RNA and protein elements of E. coli and lambda transcription antitermination complexes

Article Abstract:

A review of studies of the mechanism underlying the elongation properties of RNA polymerase is presented. The functions of the gene N and the gene Q proteins, the two transcription antiterminators of the Escherichia coli phage lambda, were characterized. Q is a DNA-binding protein that regulates RNA polymerase during an early elongation pause. N is an RNA-binding protein which prevents premature termination and which recognizes RNA via an arginine cluster domain.

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