Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
Article Abstract:
A study demonstrates that B lymphocyte-induced maturation protein 1 (Blimp1) appears to govern cellular input into the sebaceous gland (SG) since its loss leads to elevated c-myc expression, augmented cell proliferation, and SG hyperplasia. BrdU labeling experiments demonstrate that the SG defects associated with loss of Blimp 1 lead to enhanced bulge stem cell activity, suggesting that when normal SG homeostasis is perturbed, multipotent stem cells in the bulge can be mobilized to correct the imbalance.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6
Article Abstract:
Research reveals that muscle development in Drosophila requires myoblast fusion mediated by the loner gene, which encodes a guanine nucleotide exchange factor. Data show that loner is localized to subcellular sites of fusion and acts in coordination with cell surface fusion receptors by recruiting the other essential factor GTPase ARF6 involved in myoblast fusion.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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