Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops

Article Abstract:

Blocking Gibbs sampling for linkage analysis in many-looped large pedigrees is discussed. This kind of sampling combines exact local computations with Gibbs sampling to complement strengths of both, and the method can handle problems of great complexity. No other known method can handle large pedigrees with many loops in linkage analysis. This sampling method, which operates on general Bayesian networks, is applied to a 73-person linkage problem related to the long QT syndrome (LQT), a rare heart disease.

United States, Denmark, Statistical Data Included, Methods, Analysis, Bayesian statistical decision theory, Bayesian analysis, Genetic aspects, Heart diseases, Statistical sampling, Sampling (Statistics), Familial diseases, Monte Carlo method, Monte Carlo methods, Medical statistics, Linkage (Genetics), Simulated annealing (Mathematics)

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Disruption of POF1B binding to nonmuscle actin filaments is associated with premature ovarian failure

Article Abstract:

A Lebanese familial case of premature ovarian failure (POF) is described with the linkage to the long arm of the X chromosome. The study suggest that a homozygous point mutation in the candidate gene POF1B influences the pathogenesis of POF by altering POF1B binding to nonmuscle actin filaments.

Science & research, California, Health aspects, Causes of, Menopause, Actin, X chromosome

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Multilocus association mapping using variable-length Markov chains

Article Abstract:

A new method is proposed for association-based gene mapping that makes powerful use of multilocus data, is computationally efficient and is straightforward to apply over large genomic regions. The approach is based on fitting of variable-length Markov chain models.

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