Insulin-like signaling and the neural circuit for integrative behavior in C. elegans
Article Abstract:
Insulin-like signaling and the neural circuit behavior of Caenorhabditis (C) elegans were studied. It was shown that in cooperation with a secreted protein HEN-1 an insulin homolog INS-1, and insulin like signaling pathway modulate neuronal activity of interneurons to execute thermotaxis behavior in C. elegans indicating that a neuroendocrine system is important for modulating the neural circuit that underlies neural plasticity.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Dual role of autophagy in the survival of Caenorhabditis elegans during starvation
Article Abstract:
A study to show that physiological levels of autophagy act to promote survival in Caenorhabditis elegans during starvation, whereas insufficient or excessive levels of autophagy contribute to death is presented. Results show that autophagy can have either prosurvival or prodeath in an organism, depending on its level of activation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharnyx pumping and normal neurotransmission in C. elegans
Article Abstract:
Study is conducted to which mutations are done in isoforms encoding the Rho-specific RhoGeF-2 domain. It is revealed that the UNC-73 C1, C2/F, and E isoforms, via their RhoGef-2 domains, are required to activate Rho in the nervous system to modulate neurotransmission through the control of DCV secretion.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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