Brachyury downstream notochord differentiation in the ascidian embryo
Article Abstract:
Downstream notochord differentiation by Brachyury in the ascidian embryo has been studied. Brachyury is essential for notochord differentiation in vertebrates and in the ascidian tadpole, which has the most simplified chordate body design. The misexpression of the Brachyury gene (Ci-Bra) of Ciona intestinalis, an ascidian, is enough to transform endoderm into notochord. Subtractive hybridization screens were conducted to identify potential Brachyury target genes induced on Ci-Bra misexpression. The potential Ci-Bra downstream genes seem to encode a broad spectrum of divergent proteins associated with notochord formation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
A novel cis-regulatory element, the PTS, mediates an anti-insulator activity in the Drosophila embryo
Article Abstract:
Results demonstrate that the cis-regulatory sequence termed the promoter targeting sequence (PTS) aids distal enhancers to overcome blocking by Fab-8 insulator. Data further suggest that PTS mediates conversion of dominant, long-rage insulators into local regulatory elements.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
The ascidian as a model organism in developmental and evolutionary biology
Article Abstract:
Recent research reveals that developmental aspects of ascidian larva and vetebrate tadpole demonstrate similarities at evolutionary and molecular levels. Data indicate that same genes are preferentially expressed in both ascidian and vetebrate notochord and nervous systems.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo. Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos
- Abstracts: Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
- Abstracts: A spatial map of olfactory receptor expression in the Drosophila antenna. Two-photon calcium imaging reveals an odor-evoked map of activity in the fly brain
- Abstracts: A zebrafish nanos-related gene is essential for the development of primordial germ cells. Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity
- Abstracts: Differential requirement for caspase 9 in apoptotic pathways in vivo. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure