WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo
Article Abstract:
Three WNT factors have been shown to signal through beta-catenin function as critical regulators of the FGF-8/FGF-10 loop. Induction of Fgf-8 in the limb ectoderm by FGF-10 is mediated by the induction of Wnt-a. Three WNT signals mediated by beta-catenin control both limb initiation and apical ectodermal ridge (AER) induction in the vertebrate embryo.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification
Article Abstract:
The novel tyrosine kinase ZAK1, cAMP-activated and a nonreceptor, activates GSK3 to direct the specification of cell fate in Dictyostelium. Likely similar mechanisms antagonize Wnt/wingless (wg) signaling for metazoan cell fate specification. ZAK1 is downstream of 7-TM cAMP receptor signaling.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos
Article Abstract:
Research has been conducted on left-right asymmetry establishment during vertebrate embryogenesis. The authors report the existence of the mechanism which involves Notch activity translating initial symmetry breaking event into asymmetric gene expression.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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