Building better vasculature
Article Abstract:
The relative contribution of vascular endothelial growth factor (VEGF) to the formation of new vasculature is discussed in this perspectives article. Positive and negative growth factors are important in the establishment of the vascular network in embryogenesis, but new findings indicate that important new therapeutic paths for promoting angiogenesis exist. Hypoxia brings on VEGF expression, and VEGF stimulates angiogenesis.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
Article Abstract:
Ku DNA end-binding protein has been found to modulate homologous repair of double-strand breaks (DSBs) in cells of mammals and is discussed in this research communication. Neither gene-targeting frequencies nor sister-chromatid exchange shows dependence on certain NHEJ proteins. Homology-directed repair (HDR) of a DSB was analyzed in cells lacking NHEJ components.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes
Article Abstract:
Action on the part of the Igf2r imprint control element on upstream and downstream imprinted genes is discussed in this research communication. Research has shown the identity of a cluster of imprinted genes. Their repression by the bidirectional action of the Region2-ICE is independent of transcript overlap by the Air RNA.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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