CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division
Article Abstract:
CPEB, maskin, and cyclin B1 mRNA have been studied as they relate to the mitotic apparatus, and implications for local translational control of cell division considered. Two mRNAs, Xbub3 and cyclin B1, have been seen to localize with or near CPEB and maskin on spindles and centrosomes in Xenopus embryos. These and other findings indicate that the CPEB-regulated mRNA translation is important for the integrity of the mitotic apparatus and for cell division.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Control of cellular senescence by CPEB
Article Abstract:
Cytoplasmic polyadenylation element-binding protein (CPEB) is found to be a sequence-specific RNA-binding protein that promotes polyadenylation-induced translation. Exogeneous CPEB restores senescence in the knockout (KO) MEFs (embryo fibroblasts derived from the mouse) and CPEB appears to act as a translational repressor protein to control myc translation and resulting cellular senescence.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3
Article Abstract:
The fact that insulin also stimulates Aurora A-catalyzed CPEB S174 phosphorylation, cytoplasmic polyadenylation, translation and oocyte maturation, is discussed. The results of the pathways suggest that progesterone and insulin stimulates maturation by inhibiting GSK-3, allowing Aurora A activation and CPEB-mediated translation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2004
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