CYLD in ubiquitin signaling and tumor pathogenesis
Article Abstract:
CYLD is a tumor suppressor gene, the absence of which causes an inherited disease characterized by benign skin tumors. A study is presented to show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-(kappa)B and activates transcription of proliferation genes in response to growth signals.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
Article Abstract:
A single nucleotide polymorphism (SNP309) is found in the MDM2 promoter, and it is shown that it increases the affinity of the transcriptional activator Sp1, resulting in higher levels of MDM2 RNA and protein, and the subsequent attenuation of the p53 pathway. SNP309 is shown to associate with accelerated tumor formation in both hereditary and sporadic cancers in humans.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes
Article Abstract:
Gene transcription gets regulated by the retinoblastoma tumor suppressor protein (pRb). Results indicate an extensive evolutionary conservation of specific pRb repressor complexes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Biochemical and mutational analysis of a Gingipain-like peptidase activity from Prevotella ruminicola B(sub 1)4 and its role in ammonia production by ruminal bacteria
- Abstracts: Planting alfalfa and cloning the Huntington's disease gene. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
- Abstracts: Autophagy in neuronal cell loss: A road to death. Neurogenesis in adult CNS: from denial to opportunities and challenges for therapy
- Abstracts: Activity and phylogenetic diversity of bacterial cells with high and low nucleic acid content and electron transport system activity in an upwelling ecosystem
- Abstracts: SUMO and ubiquitin in the nucleus: different functions, similar mechanism?. Segmentation in vertebrates: clock and gradient finally joined