Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
Article Abstract:
The biochemical functions of the Cbfa1 core-binding factor were characterized in fetal mice with mutated Cbfa1 genes. The mutated mice died after birth due to a complete lack of bone formation that was induced by the disruption of the Cbfa1 gene. Histological analysis of the skeleton of the mice indicated the presence of low levels of osteopontin and osteolacin. Furthermore, maturational arrest occured during the early stage of osteoblast differentiation in the mutated mice embryos.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
Article Abstract:
Maturation and proliferation of and antigen receptor gene rearrangement in T cells are coordinated at two major control points. The expression of different forms of the T cell receptor influences progression through these control points. Studies show that the differentiation of immature thymocytes from double-negative to double-positive cells is regulated by a mitogen-activated protein kinase.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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