Cleavage of the plasma membrane Na+/Ca(super 2)+ exchanger in excitotoxicity
Article Abstract:
The major plasma membrane Ca(super 2)+ extruding system, the Na+/Ca(super 2)+ exchanger (NCX) that is cleared during brain ischemia and in neurons undergoing excitotoxicity is described. Proteolytic inactivation of NCX-driven neuronal Ca(super 2)+ extrusion is responsible for the delayed excitotoxic Ca(super 2)+ deregulation and neuronal death.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
The latest waves in calcium signaling
Article Abstract:
The contributions of Ca(super 2+) and Ca(super 2+) binding proteins to health and disease were addressed in a meeting held in April 2005 in Bnaff, Canada. Insights got from the mechanical studies offered the potential for new therapeutic approaches to combat a variety of diseases resulting from alterations in Ca(super 2+) homeostasis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Neuroprotection in Ischemia: Blocking calcium-permeable acid-sensing ion channels
Article Abstract:
Ca(super 2+) toxicity remains the central focus of ischemic brain injury, and acidosis is a common feature of ischemia. The study shows that acidosis activates Ca(super 2+)-permeable acid-sensing ion channels (ASICs).
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Crystal structure of mitochondrial respiratory membrane protein complex II. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain
- Abstracts: The preprotein translocation channel of the outer membrane of mitochondria. The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria
- Abstracts: Prevalence and antimicrobial resistance of thermophilic Campylobacter spp. from cattle farms in Washington State
- Abstracts: Roseobacter-like bacteria in Red and Mediterranean Sea aerobic anoxygenic photosyntheic populations. Novel primers reveal wider diversity among marine aerobic anoxygenic phototrophs
- Abstracts: Scarce evidence of yogurt lactic acid bacteria in human feces after daily yogurt consumption by healthy volunteers