Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity
Article Abstract:
A protein interaction cloning technique helps clone the Bcl-2-binding protein BAG-1-encoding cDNAs. There is no sequence homology between BAG-1 and Bcl-2 family proteins. Coexpression of Bcl-2 and BAG-1 confers enhanced protection from cell death activated by anti-Fas antibody, saturosporine and cytolytic T cells in the human lymphoid cell line Jurkat. Cell survival in 3T3 fibroblasts after an apoptotic stimulus increases due to BAG transfection, indicating that the new anti-cell death gene bag-1 regulates some of the apoptosis activation pathways, along with Bcl-2.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Cytochrom c: Can't live with it-can't live without it
Article Abstract:
Cytochrome c is important for phosphorylation in mitochondria where it helps with production of ATP. However, one of the required factors from cytosol that induces proteolytic processing and activation of the cell death protease, caspase-3, was found to be cytochrome c. Further research showed that cytochrome c is quickly released from mitochondria into the cytosol. Vander Heiden and colleagues suggest that the release of cytochrome c is due to mitochondrial swelling and rupture of outer membranes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Structural and functional dynamics of sulfate-reducing populations in bacterial biofilms. On the occurrence of anodic microniches, denitrification, and sulfate reduction in aerated activated sludge
- Abstracts: Construction and analysis of beta-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus
- Abstracts: Conditional expression of Mycobacterium smegmatis ftsZ, an essential cell division gene. Identification of the putrescine biosynthetic genes in Pseudomonas aeruginosa and characterization of agmatine deiminase and N-carbamoylputrescine amidohydrolase of the argine decarboxylase pathway
- Abstracts: Purification and characterization of a novel 5-oxoprolinase (without ATP-hydrolyzing activity) from Alcaligenes faecalis N-38A
- Abstracts: Randomly amplified polymorphic DNA analysis of Xylella fastidiosa Pierce's disease and oak leaf scorch pathotypes