Gene switching and the stability of odorant receptor gene choice
Article Abstract:
A genetic strategy is devised that allows examining the stability of receptor expression. It is observed that the majority of neurons that have chosen a specific receptor continue to express this receptor for the life of the cell, however, a subpopulation of cells switches receptor gene choice. These observations suggest a mechanism of olfactory receptor (OR) gene choice in which a cell selects only one receptor allele but can switch at low frequency.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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Science imitates art: the cloning of mice from olfactory sensory neurons
Article Abstract:
An oldfactory sensory neurons functional identity is defined by its expression of one odorant receptor from large multigene family. The complexity of this process has led to speculation that DNA rearrangements limit the expression of one receptor gene per cell.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
User Contributions:
Comment about this article or add new information about this topic: