Cometabolisn of a nongrowth substrate: L-Serine utilization by corynebacterium glutamicum
Article Abstract:
The sdaA gene is identified in the genome of C. glutamicum and overexpression of sdaA resulted in functional L-serine dehydratase activity and therefore conversion of L-serine to pyruvate. Use of 13C-labeled L-serine and analysis of cellularly derived metabolites by nuclear magnetic resonance spectroscopy reveal that the carbon skeleton of L-serine is mainly converted to pyruvate-derived metabolites such as L-alanine.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2004
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Strains of Corynebacterium glutamicum with different lysine productivities may have different lysine excretion systems
Article Abstract:
Differences in the kinetic proprties of the lysine transport systems of three different Corynebactrium glutamicum strains are discussed. Two strains were bred from classical mutagenesis and have a feedback-resistant aspartate kinase while the other strain was constructed by introducing the kinase gene into the genome of the wild type. It was found that all three genes undergo carrier-mediated lysine secretions.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 1993
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Metabolic engineering of Corynebacterium glutamicum for L-serine production
Article Abstract:
The construction of an L-serine-producing strain from Corynebacterium glutamicum by metabolic engineering is described. Metabolic engineering of L-serine production from glucose can be achieved only by addressing the apparent key position of this amino acid in the central metabolism.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2005
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