Constraints on intron evolution in the gene encoding the myosin alkali light chain in Drosophila

Article Abstract:

Investigation of nucleotide polymorphism at 991 sites in 16 randomly sampled alleles of myosin alkali light chain (Mlc1) in Drosophila melanogaster indicates that alternatively spliced exon 5 is flanked by introns 4 and 5. Both intraspecific polymorphism and interspecific divergence of introns 4 and 5 are relatively small compared to those of intron 3. Ancestral history of Mlc1 involves intragenic recombination as revealed by genealogical analysis, and occurrence of recombination is higher than mutation events. Experimental data support the presence of additional constrains on introns flanking alternatively spliced exon.

Introns

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P-element-induced variation in metabolic regulation in Drosophila

Article Abstract:

Examination of the metabolic characters of Drosophila melanogaster having single P-element insertions in a common genetic background reveals the leptokurtic distribution of mutational effects. Out of 16 characters, 13 characters show significant heterogeneity among insertion lines, indicating the large size of the mutational target for enzyme activities. A comparative study of the effects of P-element insertions enables the estimation of pleiotropic effects of single P-element insertions, which suggest the involvement of multiple forces in shaping the extant variation.

Metabolic regulation, Mutation (Biology), Mutation

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Evolutionary analyses of DNA sequences subject to constraints on secondary structure

Article Abstract:

Evolutionary models for the analysis of nucleotide sequences consider the evolution of nucleotide pairs and include base-pairing constraint effects on nucleotide substitution rates. The construction of a likelihood-ratio test for the null hypothesis that two DNA regions evolve independently demonstrate some uses of the models. Inclusion of the test into a heuristic method helps determine the position of unknown stems.

Nucleotide sequence, Base sequence

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