Conversion of BcI - 2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

Article Abstract:

The coupling of BCI - 2 with orphan nuclear receptor Nurr77 / TR3 which is required for cancer cell apoptosis is induced by many antineoplastic agents. The findings confirm that BcI - 2 manifests the opposing phenotypes, induced by interactions with Nurr77 protein, thus leading to new strategies to regulate apoptosis in cancer and other diseases.

Science & research, Research, Prognosis, Protein synthesis, Cell receptors, Protein biosynthesis, Apoptosis

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Two enzymes in one: two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function

Article Abstract:

Two cytosolic yeast peroxiredoxins (Prxs), cPrxl and II with diverse structures and apparent molecular weights, can act alternatively as peroxidases and molecular chaperones. The chaperone function of their protein structures enhances yeast resistance to heat shock.

Food preparations, not elsewhere classified, Enzymes, Other Basic Organic Chemical Manufacturing, All Other Miscellaneous Food Manufacturing, Yeast, Yeast (Food product), Molecular structure, Atomic properties, Molecular chaperones

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