Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements
Article Abstract:
The crystal structure of the thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 Angstrom resolution is presented. The differences between the conformations of vacant and tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure in response to tRNA binding, including significant changes in the peptidyl-transferase catalytic site.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Bacteria, Thermophilic, Ribosomes, Structure, Thermophiles
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Noncanonical function of Glutamly-Prolyl-tRNA synthetase: gene-specific silencing of translation
Article Abstract:
Ligation of amino acids is catalyzed by aminoacyl tRNA synthetases to cognate tRNAs. It is found that GluProRS has divergent functions in protein synthesis.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
Protein synthesis, Protein biosynthesis, Ligases
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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Subjects list: Research, Transfer RNA
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