Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

Article Abstract:

The X-ray crystal structure of the tNS3 NS3 proteinase domain complexed with the NS3-binding region of NS4A is composed of two asymmetric units of tNS3:NS4A molecules. The complex exhibits a three dimensional structure that that adopts a chemotrypsin-like fold with two structural domains that is made of twisted and six-stranded beta sheets. Furthermore, the crystal structure of the complex is similar to the Sinbis virus core protein.

Analysis, Enzymes, Recombinant proteins, Enzyme structure-activity relationships

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Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein

Article Abstract:

Research was conducted to determine the crystal structure of the hexamerization domain of the N-ethylmaleimide-sensitive fusion protein, a cytosolic adenosine triphosphatase. At 1.75 A resolution, the structure was found to be composed of a nucleotide-binding and a helical domain. This structure exhibited similarities with the first two domains of the clamp-loading subunit of Escherichia coli's DNA polymerase III.

Adenosine triphosphatase

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The structure of a Ca2+ -binding epidermal growth factor-like domain: its role in protein-protein interactions

Article Abstract:

The crystal structure of Ca2+ binding to epidermal growth factor-like (EGF-like) domains was determined at high resolution using human clotting factor IX complexed with Ca2+. Seven calcium ligands were identified indicating that Ca2+ binds to EGF-like domains, stabilizes the protein and mediates protein-protein interactions. EGF-like domains are common in many extracellular proteins.

Calcium-binding proteins, Calcium binding proteins

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