DNA structures at chromosomal translocation sites
Article Abstract:
The work on non-B DNA conformations, as the possible basis for certain consistent sites of chromosomal translocation was assessed and summarized. It indicates that some of the most common fragile sites in human neoplasm assume non-B DNA structures and because of the single strandedness within these non-B structures, they are vulnerable to structure specific nucleases.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2006
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The evolution of meiosis: Recruitment and modification of somatic DNA-repair proteins
Article Abstract:
Several examples of proteins exhibiting functional differentiation between somatic DNA repair and meiotic homologous recombination are presented. Somatic repair functions and meiotic recombination diverged during evolution resulting in adaptations specific to sexual reproduction.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
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Human severe combined immune deficiency and DNA repair
Article Abstract:
Human severe combined immune deficiency (SCID) is the most serious inherited immunological deficit. Various defects in the predominant pathway for double-strand break repair called nonhomologous DNA end joining are revealed.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2003
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