Dancing around the divisome: Asymmetric chromosome segregation in Escherichia coli
Article Abstract:
A new scheme for the relationship between DNA replication-segregation, chromosome organization, and cell division is developed by simultaneously tracking pairs of specific genetic regions and divisome proteins in live Escherichia coli. A remarkable asymmetric pattern of segregation of different loci in the replication termination region suggests that individual replichores segregate to distinct nucleoid positions, consistent with an asymmetric segregation of leading and lagging strand templates after replication.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability
Article Abstract:
Common fragile sites are specific chromosomal loci that form gaps on metaphase chromosomes exposed to replication stress that shows DNA replication. Replication stress leads to formation of RAD51 and phosphorylated DNA-Pkcs, key components of the homologous recombination (HR) and nonhomologous end-joining (NHEJ), double-strand break (DSR) repair pathways and studies shows that HR and NHEJ repair pathways can be coupled to repair DSK and to maintain site stability.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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The two Escherichia coli chromosome arms locate to separate cell halves
Article Abstract:
DNA replication, which divides the circular Escherichia coli chromosome into equal arms, is described. Sequential replication-segregation regenerates the
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
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