Degradation of mRNA in eukaryotes
Article Abstract:
More than one pathway exists for the degradation of mRNA, but deadenylation or shorting of poly(A) tails appears to be a default pathway that applies to some extent to all polyadenylated mRNAs. Deadenylation may be followed by decapping and 5' to 3' decay or by 3' to 5' decay. In addition, there are mechanisms that apply to specific mRNA classes or individuals, such as deadenylation-independent capping and sequence-specific endonucleolytic cleavage. Decay rate is also affected by cis-acting sequences, while other factors may affect turnover of mRNA.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
General translational repression by activators of mRNA decapping
Article Abstract:
The decapping activators Dhh1p and Pat1p are identified as functioning as translational repressors and facilitators of processing body formation. The results identify a broadly acting mechanism of translational repression that targets mRNAs for decapping and functions in translational control.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Control of translation and mRNA degradation by miRNAs and siRNAs
Article Abstract:
The possible mechanisms by which exogenous micro RNAs (miRNAs) and short interfering RNAs (siRNAs) control translation and degradation of mRNA is discussed. It is found that miRNAs and siRNA, target mRNA to the general eukaryotic cytoplasm for mRNA decay and translation control.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A CBP integrator complex mediates translational activation and AP-1 inhibition by nuclear receptors. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
- Abstracts: Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Histone lysine demethylases and their impact on epigenetics
- Abstracts: Identification of bacteria potentially responsible for oxic and anoxic sulfide oxidation in biofilters of a recirculating mariculture system
- Abstracts: Proteomic analysis of extracellular proteins from Aspergillus oryzae grown under submerged and solid-state culture conditions
- Abstracts: Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance