Developmental regulation of Fos-protein during proliferative growth of the otic vesicle and its relation to differentiation induced by retinoic acid
Article Abstract:
Experimental studies reveal that Fos-protein expression during proliferative growth of the otic vesicle is developmentally regulated. Transition between cell proliferation and differentiation is regulated by the Fos regulation. Fos expression and growth of otic vesicle are suppressed by both retinoic acid and antisense oligonucleotides. Hair-cell differentiation is stimulated only by retinoic acid. Fos participates in the signaling mechanism, which regulates the normal development of the inner ear.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Anti-retinoic acid monoclonal antibody localizes all-trans-retinoic acid in target cells and blocks normal development in early quail embryo
Article Abstract:
All-trans-retinoic acid is required for normal cardiovascular development and for early development events in the quail embryo. During the development of the quail embryo, it is biosynthesized in the Hensen's node and in the caudal area during stage 5 and in heart-forming areas, head mesenchyme and nephrotome in stage 7 and 8. A monoclonal antibody against all-trans-retinoic acid blocks normal embryonic development in the quail embryo, causing cardiovascular abnormalities.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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Galectin-7, a human 14-KDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid
Article Abstract:
A 14 kDa S-lectin called galectin-7 has been isolated in cultures of human skin cells. The expression of this lectin in keratinocyte cultures was inhibited by retinoic acid, which is involved in the growth and differentiation of skin. It appears to be expressed in all layers of skin and has a different sequence than other S-lectins.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
User Contributions:
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