Directional sensing requires G(beta)(gamma)-mediated PAK1 and PIX(alpha)-dependent activation of Cdc42
Article Abstract:
Research has been conducted on G(beta)(gamma), PAK-associated guanine nucleotide exchange factor (PIX(alpha)), Cdc42 and p21-activated kinase (PAK). The authors describe the signaling mechanism involving G(beta)(gamma), PIX(alpha), Cdc42 and PAK, and they suggest that G(beta)(gamma) binds PAK1 and activates Cdc42 via PAK-associated PIX(alpha), and that in turn Cdc42 activates PAK1.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Journey to the center of the cell
Article Abstract:
The author reviews the publications on the mechanisms used by the pathogenic human viruses to cross the plasma membrane. The topics of interest include retroviruses, adenoviruses, herpes viruses and influenza viruses.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The mitochondrial toxin produced by Streptomyces griseus strains isolated from an indoor environment is valinomycin
- Abstracts: Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
- Abstracts: Methylation-induced repression: belts, braces and chromatin. Nuclear visions: functional flexibility from structural instability
- Abstracts: A 700 bp cis-acting region controls mating-type dependent recombination along the entire left arm of yeast chromosome III
- Abstracts: Role of Dlx6 in regulation of an endothelin-1-dependent dHAND branchial arch enhancer. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2