Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding

Article Abstract:

Targeting of Ikaros, a sequence-specific DNA-binding protein essential for lymphocyte development, to pericentromeric heterochromatin is discussed. It is achieved by direct DNA binding. Results may be consistent with presence of Ikaros binding sites within centromeric DNA repeats.

Cytochemistry, DNA binding proteins

---

Down-regulation of TDT transcription in DC4(super.+)CD8(super.+) thymocytes by Ikaros proteins in direct competition with an Ets activator

Article Abstract:

Research findings indicate that Ikaros, a regulator of lymphopoiesis, has a direct role in heritable gene inactivation. Mutations that selectively disrupt Ikaros binding to an integrated gene-encoding terminal transferase (TdT) promoter stopped down-regulation on differentiation.

Gene expression

---

Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin

Article Abstract:

Helios, the p70 gene, is a T cell-restricted Ikaros family member. It associates with Ikaros isoforms without discrimination when overexpressed and associates quantitatively with Ikaros at centromeric heterochromatin. Ikaros is in most hematopoietic cells. Only a fraction of the Ikaros, likely that associated with Helios, localizes centromerically in T cells. It seems Helios is a limiting regulatory subunit for Ikaros within centromeric heterochromatin. Immunoaffinity chromatography is useful in identifying Ikaros partners.

Usage, T cells, Immunological research, Immunologic research, Chromatography

Similar abstracts:

• Abstracts: Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3
• Abstracts: The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole
• Abstracts: Colonization of Arabidopsis thaliana with Salmonella enterica and enterohemorrhagic Escherichia coli O157:H7 and competition by Enterobacter asburiae
• Abstracts: Investigation of the translation-initiation factor IF2 gene, infB, as a tool to study the population structure of Streptococcus agalactiae
• Abstracts: Distinct functions of the leucine-rich repeat transmembrane proteins Capricious and Tartan in the Drosophila tracheal morphogenesis

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.