ESCRT-I core and ESCRT-II glue domain structures reveal role glue in linking to ESCRT-I and membranes
Article Abstract:
The yeast ESCRT-I links directly to ESCRT-II, through a tight interaction of Vps28 (ESCRT-I) with the yeast-specific zinc finger insertion with the GLUE domain of Vps36 (ESCRT-II). The crystal structure of the GLUE domain missing this insertion reveals it is a split PH domain, with a noncanonical lipid binding pocket that binds Ptdins3P.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma
Article Abstract:
Results demonstrate that the Ras activation of phosphoinositide 3-kinase gamma is brought about by positioning Ras by a loop in the binding domain such that the enzyme binds to switch I and II regions of Ras. Data suggest that the same interactions may occurr in the alpha-form-Ras binding.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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Structural insight into the mechanism of double-stranded RNA processing by Ribonuclease IIIX
Article Abstract:
The crystal structure of an RNase III-product complex, the first catalytic complex observed for the family is presented. The structure reveals a wealth of information about the mechanism of RNA hydrolysis that can be extrapolated to other RNase III family members.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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