Emilin1 links TGF-beta maturation to blood pressure homeostasis
Article Abstract:
An unprecedented link between TGF-beta signaling and arterial hypertension is reported based on the analysis of mice mutant for Emilin1, as cysteine-rich secreted glycoprotein expressed in the vascular tree. The study highlights the importance of modulation of TGF-beta availability in the pathogenesis of hypertension.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
Article Abstract:
Ecto is a RING-type ubiquitin ligase for Smad4, a TGF-beta signal transducer. It is proposed that Ectodermin is a key to switch in the control of TGF-beta gene responses during early embryonic development and cell proliferation.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads
Article Abstract:
Research has been conducted on p53 tumor suppressor which regulates cell proliferation, differentiation and apoptosis. The authors demonstrate that p53 can physically interact with Smad2 in TGF-beta-dependent manner.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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