End-product control of expression of branched-chain amino acid biosynthesis genes in Streptomyces coelicolor A3(2): paradoxical relationships between DNA sequence and regulatory phenotype
Article Abstract:
Branched-chain amino acid biosynthesis genes in Streptomyces coelicolor A3(2) are discussed relative to end-product control of their expression. Paradoxical relationships have been observed between DNA sequence and the regulatory phenotype. The branched-chain protein amino acids of interest are leucine, isoleucine and valine and they can give precursors for synthesis of complex polyketide secondary metabolites in streptomycetes.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production
Article Abstract:
Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces avermitilis and Streptomyces coelicolor are discussed. They give insights into metabolism of macrolide antibiotic production and small branched-chain fatty acids. S. coelicolor and S. avermitilis genes encoding an acyl-CoA dehydrogenase thought to be involved in the catabolism of branched-chain amino acids were cloned.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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