Endless forms: the evolution of gene regulation and morphological diversity

Article Abstract:

The evolution of gene regulation and morphological diversity is discussed in this minireview. Mounting evidence indicating a central role for differences in developmental gene regulation in intraspecific variation and body plans and body parts diversification is reviewed with changes in the cis-regulatory systems of genes and why changes in them more often are behind the evolution of morphological diversity than are changes in protein function or gene number. The sufficiency of evolutionary mechanisms seen below or at the species level to account for the larger scale patterns of morphological evolution is discussed from the developmental genetic perspective.

Morphology (Biology), Biological diversity, Biodiversity, Evolution (Biology), Genetic regulation, Developmental genetics, Evolution, Morphology

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Double-stranded RNA as a template for gene silencing

Article Abstract:

Double-stranded RNA (dsRNA), which can be seen as a template for gene silencing, is discussed in this minireview article. Posttranscriptional gene silencing (PTGS) that occurs when double-stranded RNA (dsRNA) corresponding to a sense and antisense sequence of an endogenous mRNA is introduced into a cell, the cognate mRNA is degraded and the gene is silenced, is of interst. PTGS likely reflects a natural biological process.

Suppression, Genetic, Suppressor mutation (Molecular genetics), RNA

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Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye

Article Abstract:

Overlapping repressors and activators have been found to delimit transcriptional response to Drosophila eye receptor tyrosine kinase signals. It has been shown that prospero is controlled by signals from the EGF receptor DER and the Sevenless receptor. Sevenless activates prospero independent of the enhancer and involves targeted degradation of the transcription repressor Tramtrack.

Statistical Data Included, Physiological aspects, Eye, Protein tyrosine kinase, Protein-tyrosine kinase, Drosophila, Epidermal growth factor, Epidermal growth factors

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