Effect of FGF on gene expression in chick limb bud cells in vivo and vitro

Article Abstract:

The fibroblast growth factors (FGFs), FGF-2 and FGF-4, ensure the expression of Msx-1, Hoxd-13 and Bmp-2 in the posterior limb bud mesenchyme of chicken embryos. Expression of these genes are sensitive to the local signal from the apical ectodermal ridge. In the anterior cells of early bud stages, the expression of Msx-1 is based on the signals from the anterior apical ectodermal ridge. The expression of Hoxd-11 in the posterior mesenchyme is independent of the apical ectodermal ridge or FGF.

Physiological aspects, Growth, Gene expression, Morphogenesis, Extremities (Anatomy)

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BMP-4 regulates the dorsal-ventral differences in FGF/MAPKK-mediated mesoderm induction in Xenopus

Article Abstract:

Molecular evidence shows that bone morphogenetic protein-4 (BMP-4) is essential in regulating mesodermal gene expression induced by the fibroblast growth factor (FGF)/mitogen-activated protein kinase kinase pathway in Xenopus embryo. In the absence of BMP-4, expression of the mesodermal genes containing the FGF and BMP receptors in the dorsal and ventral regions of the embryo are not maintained. Furthermore, coexpression of FGF and BMP receptors is also eliminated.

Cellular signal transduction, Genetic regulation, Genetic transcription, Transcription (Genetics), Xenopus, Mesoderm

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