From amplification to gene in thyroid cancer: a high-resolution mapped bacterial artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization

Article Abstract:

Comparative genome hybridization (CGH) combined with a dense mapped resource of bacterial artificial chromosomes (BACs) and large-scale sequencing has led to definition of a candidate gene previously unmapped and related to thyroid tumorigenesis. CGH data can be translated into higher resolution genomic-clone data that are used to define genes in aneuploid regions by using a newly developed general approach. The CGH method has been used to investigate thyroid-tumor DNAs and two tumor-cell-line DNAs. Amplifications of chromosome band 2p21 were found, and less intense amplification was found elsewhere..

Methods, Genetic aspects, Chromosome mapping, Carcinogenesis, Gene amplification, Thyroid cancer

---

Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24

Article Abstract:

Further research is needed to determine causal factors for autosomal dominant nocturnal frontal-lobe epilepsy. While evidence suggests a second locus for the disorder at chromosome 15q24 in addition to 20q13.2 with a clinically homogeneous phenotype, a wide range of molecular defects that contribute to the disorder are complicating accurate causal determination.

Epilepsy, Genetic disorders

---

Similar abstracts:

• Abstracts: Relationship between bacterial counts and endotoxin concentrations in the air of wastewater treatment plants. Influence of various dust sampling and extraction methods on the measurement of airborne Endotoxin
• Abstracts: Improved enumeration of lactic acid bacteria in mesophilic dairy starter cultures by using multiplex quantitative real-time PCR and flow cytometry-fluorescence in situ hybridization
• Abstracts: Genealogy of the nuclear [beta]-fibrinogen locus in a highly structured lizard species: Comparison with mtDNA and evidence for intragenic recombination in the hybrid zone
• Abstracts: Paraoxonase-gene polymorphisms associated with coronary heart disease: support for the oxidative damage hypothesis?

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.