Paraoxonase-gene polymorphisms associated with coronary heart disease: support for the oxidative damage hypothesis?
Article Abstract:
Polymorphisms of the gene controlling paraoxonase have been associated with increased risk of coronary heart disease. The exact physiological role of the serum enzyme paraoxonase is not known. However, it is a component of HDL and may provide a link between HDL levels and coronary heart disease. The oxidation hypothesis suggests a role for paraoxonase in atherosclerosis.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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A Bayesian measure of the probability of false discovery in genetic epidemiology studies
Article Abstract:
The article describe on how Bayesian false-discovery probability (BFDP) can be used for design and multiple-hypothesis' testing context providing the expected numbers of false and missed discoveries.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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New perspective for the elucidation of genetic disorder
Article Abstract:
The article describes the new ways derived for the elucidation of genetic disorder like coronary heart disease, stroke, dementia, psychiatric disorder, asthma, and cancer.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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- Abstracts: A unique point mutation in the PMP22 gene is associated with Charcot-Marie-Tooth disease and deafness. Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia
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- Abstracts: Simple multiple-marker sib-pair analysis for mapping quantitative trait loci. Parentage and sibship exclusions: higher statistical power with more family members